Primary resistance to tamoxifen
WebAbstract: Tamoxifen was the first targeted anticancer agent for breast cancer patients and its effects on reduction of breast cancer events and improvement in overall survival are undisputed. Hence, it has long been considered an essential part of patient care. Recent results of several large adjuvant hormonal trials evaluating the use of ... WebBACKGROUND: Recently, a novel variant of ER-alpha, ER-alpha36 was identified and cloned. ER-alpha36 lacks intrinsic transcription activity and mainly mediates nongenomic estrogen signaling. Here, we studied the role of nongenomic estrogen signaling pathways mediated by ER-alpha36 in tamoxifen resistance and agonist action.
Primary resistance to tamoxifen
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Webtreatment is the primary treatment for these cases and improves patient outcome (Palmieri et al, 2014. )ER negative disease is heterogeneous and has poorer outcome ... constitute a possible mechanism for tamoxifen resistance, however, these findings are based on in vitro analysis and a small (n=9) ... WebApr 10, 2024 · At present, research on the prevalence of primary drug resistance (PDR) in Hunan Province is limited. Therefore, we explored the current status of HIV-1 PDR in Hunan to provide a basis for antiretroviral therapy (ART) and a theoretical foundation for prevention and control of the HIV/AIDS epidemic. Three hundred seventy newly diagnosed HIV-1 …
WebBoth primary and acquired resistance to the growth-inhibitory effects of anti-estrogens (e.g., tamoxifen) limits the clinical usefulness of these drugs in the treatment of breast cancer. … WebThe results showed that primary tumors from W6 and W8 mice were sensitive to tamoxifen (Figure 1A,B), whereas primary tumors from W10 and W12 mice were not (Figure 1C,D). ER α expression has been reported to be a crucial determinant of the response to tamoxifen therapy; [ 17 , 18 ] therefore, we detected ER α expression in the primary tumors of W6, …
WebBreast cancer is the most common nondermatological malignant neoplasm in women, with an estimated 232 670 new diagnoses in 2014, and is the second leading cause of cancer death in women, with an estimated 40 000 women in the United States dying from the disease in 2014. 1 Although often curable when localized to the breast and local lymph …
RPTKs are a class of enzyme-linked receptors that have been found to come in many kinds, including epidermal growth factor (EGF) receptor, platelet-derived growth factor (PDGF) receptor, macrophage colony stimulating factor (M-CSF), insulin and insulin-like growth factor-1 (IGF-1) receptor, vascular endothelial … See more Based on the aforementioned mechanism, some enzymes and transcription factors also play a vital role in the complex network of ER-positive breast cancer … See more Endocrine therapy is extremely important for ER-positive breast cancer patients. It mainly includes selective estrogen receptor modulators (SERMs), estrogen … See more
WebA total of 218 primary breast cancer patients receiving adjuvant tamoxifen with a median follow-up of 106 months were analyzed, of which 17 (7.8%) experienced recurrence or metastasis. In an immunohistochemical (IHC) stain, SET overexpression was independently associated with worse recurrence-free survival (RFS) (hazard ratio = 3.72, 95% confidence … people of sweden calledWebJul 24, 2015 · The problem of drug-resistance is a major clinical concern for the successful management of cancer patients. Estrogen receptor (ER) is expressed in 75 % of breast cancers [] and for such breast cancers, tamoxifen is one of the important drug of choice for targeted personalized therapy.Tamoxifen can significantly lower the chances of … people of taiwan picturesWebDec 10, 2015 · The tumor samples were obtained during surgery for primary breast cancer and all patients were treated with first-line tamoxifen therapy only after disease … people of sri lanka imagesWebAug 1, 2009 · A study that evaluated the possible connection between HER2, ER, PR, and tamoxifen resistance in a tissue database linked to clinical outcomes found that intrinsic … people of st kittsWebThe primary mechanism of tamoxifen resistance is lack of ERα expression [69], therefore, miRNAs that directly target ERα, such as miR221/222, have been implicated [74]. … people of st elizabeth jamaicaWebNov 29, 2013 · Tamoxifen is widely used to treat hormone-dependent breast cancer, but its therapeutic benefit is limited by the development of drug resistance. Here, we investigated the role of estrogen G-protein coupled receptor 30 (GPR30) on Tamoxifen resistance in breast cancer. Primary tumors (PTs) of breast cancer and corresponding metastases … to get a birth certificate in nyWebJul 15, 2024 · Purpose: Treatment resistance is the main cause of adverse disease outcome in breast cancer patients. Here, we aimed to investigate common features in tamoxifen … toge sprout